医学超声图像处理系统

超声图像诊断是与X线CT、同位素扫描、核磁共振等一样重要的医学图像诊断手段。根据肝脏超声图像进行脂肪肝的诊断,是病变确诊的主要方法。但是,与CT和核磁共振等医学图像相比,超声图像的图像质量较差,目前的诊断以定性为主,受主观因素影响较大。以图像分割为基础,以VC语言为工具,建立了超声图像处理系统,对超声图像进行了二值化处理,并对处理结果进行了量化,为诊断提供了依据。     

故县大坝变形监测存在的问题及自动化改造初步设想

介绍了故县大坝变形监测系统的构成及存在的问题，并根据故县大坝的实际情况，提出了实施自动化改造的初步设想。     

哈得逊隆起下石炭统基准面旋回与储集层预测

依据基准面旋回原理和方法,综合利用哈得逊地区的钻井、测井、地震以及地球化学资料,在研究区下石炭统识别出1个Ⅰ型和3个Ⅱ型层序界面,将哈得逊地区下石炭统划分为3个中期基准面旋回：SC1、SC2、SC3,对应于早石炭世海侵的3个海进-海退旋回.SC1旋回以滨岸砂坝沉积为主,而SC2、SC3旋回发育潮坪沉积体系.研究认为,SC1旋回滨岸砂岩及SC2下降半旋回的潮间带薄层砂岩为有利储集砂体,是地层-岩性型油气藏的重点勘探目标.     

HACCP在保健食品西洋参口服液生产中的应用

保健食品行业GMP的实施有利HACCP的应用推广。本文应用HACCP于传统保健食品西洋参口服液生产过程中，将生产及加工过程中危害因素降最低限度，以确保产品的质量与安全。     

GPRS业务模型和无线网络的研究

根据GPRS业务及业务发展情况，对GPRS业务模型进行深入研究，并对GPRS无线网络进行了更深入的探讨。     

High-resolution HLA-DRB typing using denaturing gradient gel electrophoresis and direct sequencing

Skeletal development of transgenic mice with a type II collagen mutation was analyzed and compared with wild-type littermates. The single base substitution in Col2a1 resulted in a glycine to serine mutation within the helical domain and corresponded to one previously identified in a patient with the lethal human chondrodysplasia, hypochondrogenesis (Horton et al. [1992] Proc. Natl. Acad. Sci. U.S.A. 89:4583-4587). Skeletal staining of embryos from 14.5 through 18.5 days of gestation demonstrated a dwarf phenotype in the transgenic embryos, most notably short limb bones and vertebral column that was first detected at 15.5 days post-coitus. In addition to the reduced length, the extent of ossification was less in the transgenic mice. The architecture of the long bone growth plate was abnormal in the transgenic tissue, in particular there was no discernible proliferative zone. There were few stacks of characteristically flattened cells and the overall length of the growth plate in the mutant embryos was reduced. At the ultrastructural level, there were fewer collagen fibrils present in the transgenic mouse cartilage compared to that of wild-type littermates. Ultrastructural localization of collagen types II, IX and XI revealed a similar pattern between the transgenic and wild-type pups, suggesting that the collagen fibrils present in the matrix of littermates with both phenotypes had a similar composition. Skeletal analysis and cartilage histochemistry indicated that effect of the type II collagen mutation was to reduce the density of the collagen fibrils within the cartilage matrix which was associated with delayed bone formation and resulted in a short-limbed phenotype.     

Homonucleotide tracts, short repeats and CpG/CpNpG motifs are frequent sites for heterogeneous mutations in the neurofibromatosis type 1 (NF1) tumour-suppressor gene

Glutamatergic synaptic potentials induced by micromolar concentrations of the potassium conductance blocker 4-aminopyridine (4-AP) were recorded intracellularly from rat neostriatal neurons in the presence of 10 microM bicuculline (BIC). These synaptic potentials originate from neostriatal cortical and thalamic afferents and were completely blocked by 10 microM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) plus 100 microM D-2-amino-5-phosphonovaleric acid (2-APV). Their inter-event time intervals could be fitted to exponential distributions, suggesting that they are induced randomly. Their amplitude distributions had most counts around 1 mV and fewer counts with values up to 5 mV. Since input resistance of the recorded neurons is about 40 M omega, the amplitudes agree to quantal size measurements in mammalian central neurons. The action of a D2 agonist, quinpirole, was studied on the frequency of these events. Mean amplitude of synaptic potentials was preserved in the presence of 2-10 microM quinpirole, but the frequency of 4-AP-induced glutamatergic synaptic potentials was reduced in 35% of cases. The effect was blocked by the D2 antagonist sulpiride (10 microM). Input resistance, membrane potential, or firing threshold did not change during quinpirole effect, suggesting a presynaptic site of action for quinpirole in some but not all glutamatergic afferents that make contact on a single cell. The present experiments show that dopaminergic presynaptic modulation of glutamatergic transmission in the neostriatum does not affect all stimulated afferents, suggesting that it is selective towards some of them. This may control the quality and quantity of afferent flow upon neostriatal neurons.     

Classification of the effectiveness of combination treatments

According to FDA regulations, a combination drug is not efficacious unless each component contributes to the claimed effects. For a univariate endpoint, this implies that the combination at specific doses must be superior to each of its components at the same doses. More demanding is the property of synergy, in which the effect of the combination must be superior to the effect expected based on those of its components. If it is equal to those effects, it is additive, and if it is inferior, it is antagonistic. We give regions in the combination dose plane where these concepts are well defined. If the effect of the combination is greater than the greatest effect achievable by any of its components it is therapeutically synergistic. A combination can be antagonistic, yet its components can still contribute to the claimed effects. If it is additive, synergistic or therapeutically synergistic, its components must contribute to the claimed effects. We relate these concepts and provide designs and sequential procedures for determining whether a combination is therapeutically synergistic, synergistic, additive, antagonistic and contributing or antagonistic and non-contributing.